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Important publications
Organoids derived from mouse and human stem cells have recently emerged as a powerful tool to study organ development and disease. We here established a three-dimensional (3D) murine bronchioalveolar lung organoid (BALO) model that allows clonal expansion and self-organization of FACS-sorted...
Vázquez-Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Rupp MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty RE, Vadasz I, Schwemmle M, Kummer W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S
EMBO J, 2020. 39:e103476
While severe coronavirus infections, including Middle East respiratory syndrome coronavirus (MERS-CoV) cause lung injury with high mortality rates, protective treatment strategies are not approved for clinical use. OBJECTIVES: We elucidated the molecular mechanisms by which the cyclophilin...
Sauerhering L, Kupke A, Meier L, Dietzel E, Joppe J, Gruber AD, Gattenloehner S, Witte B, Fink L, Hoffmann N, Zimmermann T, Goesmann A, Nist A, Stiewe T, Becker S*, Herold S*, Peteranderl C*
Eur Respir J , 2020. 56:1901826
Influenza virus infections pose a major public health threat, accounting for 3.5 million severe infections and more than 400,000 deaths globally each year (1). Most seasonal vaccines consist of inactivated influenza virus components, which induce antibody responses against...
Science, 2020. 367(6480):852-853.
Idiopathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with unknown etiology. Due to a lack of effective treatment, IPF is associated with a high mortality rate. The hallmark feature of this disease is the accumulation of activated myofibroblasts that...
El Agha E, Moiseenko A, Kheirollahi V, De Langhe S, Crnkovic S, Kwapiszewska G, Kosanovic D, Schwind F, Schermuly RT, Henneke I, MacKenzie B, Quantius J, Herold S, Ntokou A, Ahlbrecht K, Morty RE, Gunther A, Seeger W, Bellusci S
Cell Stem Cell , 2017 20(2): 261-73 e3.
Influenza A viruses (IAV) can cause lung injury and acute respiratory distress syndrome (ARDS), which is characterized by accumulation of excessive fluid (edema) in the alveolar airspaces and leads to hypoxemia...
Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadasz I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S.
J Clin Invest, 2016. 126(4): 1566-80.
Granulocyte/macrophage colony–stimulating factor (GM-CSF) is a myeloid growth factor, which induces proliferation and differentiation of macrophages and dendritic cells. Recently, several publications highlighted GM-CSF as highly protective in different preclinical models of...
Herold S, Hoegner K, Vadasz I, Gessler T, Wilhelm J, Mayer K, Morty RE, Walmrath HD, Seeger W, Lohmeyer J.
Am J Respir Crit Care Med. 189(5):609-11, 2014.
Influenza viruses (IVs) cause pneumonia in humans with progression to lung failure. Pulmonary DCs are key players in the antiviral immune response, which is crucial to restore alveolar barrier function. The mechanisms of expansion and activation of pulmonary DC populations in lung infection...
Unkel B, Hoegner K, Clausen BE, Lewe-Schlosser P, Bodner J, Gattenloehner S, Janssen H, Seeger W, Lohmeyer J, Herold S.
J Clin Invest, 2012. 122(10): 3652-64.
Exudate macrophages are key players in host defense toward invading pathogens. Their antiinflammatory and epithelial-protective potential in gram-negative pneumonia, however, remains elusive.
Herold S, Tabar TS, Janssen H, Hoegner K, Cabanski M, Lewe-Schlosser P, Albrecht J, Driever F, Vadasz I, Seeger W, Steinmueller M, Lohmeyer J.
Am J Respir Crit Care Med, 2011. 183(10): 1380-90.
Resident alveolar macrophages have been attributed a crucial role in host defense toward pulmonary infection. Their contribution to alveolar repair processes, however, remains elusive.
Cakarova L, Marsh LM, Wilhelm J, Mayer K, Grimminger F, Seeger W, Lohmeyer J, Herold S.
Am J Respir Crit Care Med, 2009. 180(6): 521-32.
Mononuclear phagocytes have been attributed a crucial role in the host defense toward influenza virus (IV), but their contribution to influenza-induced lung failure is incompletely understood.
Herold S, Steinmueller M, von Wulffen W, Cakarova L, Pinto R, Pleschka S, Mack M, Kuziel WA, Corazza N, Brunner T, Seeger W, Lohmeyer J.
J Exp Med, 2008. 205(13): 3065-77.